Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats.
Identifieur interne : 002139 ( Main/Exploration ); précédent : 002138; suivant : 002140Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats.
Auteurs : Karim Mukhida [Canada] ; Behnam A. Baghbaderani ; Murray Hong ; Matthew Lewington ; Timothy Phillips ; Marcus Mcleod ; Arindom Sen ; Leo A. Behie ; Ivar MendezSource :
- Neurosurgical focus [ 1092-0684 ] ; 2008.
English descriptors
- KwdEn :
- Amphetamine (pharmacology), Animals, Behavior, Animal (drug effects), Bioreactors, Cell Differentiation (physiology), Cell Movement (physiology), Cell Survival, Central Nervous System (cytology), Central Nervous System (embryology), Central Nervous System Stimulants, Disease Models, Animal, Embryonic Stem Cells (physiology), Female, Fetus, Humans, Neurons (physiology), Parkinson Disease (etiology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Rats, Rats, Wistar, Stem Cell Transplantation (methods).
- MESH :
- chemical , pharmacology : Amphetamine.
- cytology : Central Nervous System.
- drug effects : Behavior, Animal.
- embryology : Central Nervous System.
- etiology : Parkinson Disease.
- methods : Stem Cell Transplantation.
- pathology : Parkinson Disease.
- physiology : Cell Differentiation, Cell Movement, Embryonic Stem Cells, Neurons.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Bioreactors, Cell Survival, Central Nervous System Stimulants, Disease Models, Animal, Female, Fetus, Humans, Rats, Rats, Wistar.
Abstract
Fetal tissue transplantation for Parkinson disease (PD) has demonstrated promising results in experimental and clinical studies. However, the widespread clinical application of this therapeutic approach is limited by a lack of fetal tissue. Human neural precursor cells (HNPCs) are attractive candidates for transplantation because of their long-term proliferation activity. Furthermore, these cells can be reproducibly expanded in a standardized fashion in suspension bioreactors. In this study the authors sought to determine whether the survival, differentiation, and migration of HNPCs after transplantation depended on the region of precursor cell origin, intracerebral site of transplantation, and duration of their expansion.
DOI: 10.3171/FOC/2008/24/3-4/E7
PubMed: 18341411
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001024
- to stream PubMed, to step Curation: 001024
- to stream PubMed, to step Checkpoint: 001024
- to stream Ncbi, to step Merge: 000887
- to stream Ncbi, to step Curation: 000887
- to stream Ncbi, to step Checkpoint: 000887
- to stream Main, to step Merge: 002323
- to stream Main, to step Curation: 002139
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats.</title><author><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Baghbaderani, Behnam A" sort="Baghbaderani, Behnam A" uniqKey="Baghbaderani B" first="Behnam A" last="Baghbaderani">Behnam A. Baghbaderani</name></author><author><name sortKey="Hong, Murray" sort="Hong, Murray" uniqKey="Hong M" first="Murray" last="Hong">Murray Hong</name></author><author><name sortKey="Lewington, Matthew" sort="Lewington, Matthew" uniqKey="Lewington M" first="Matthew" last="Lewington">Matthew Lewington</name></author><author><name sortKey="Phillips, Timothy" sort="Phillips, Timothy" uniqKey="Phillips T" first="Timothy" last="Phillips">Timothy Phillips</name></author><author><name sortKey="Mcleod, Marcus" sort="Mcleod, Marcus" uniqKey="Mcleod M" first="Marcus" last="Mcleod">Marcus Mcleod</name></author><author><name sortKey="Sen, Arindom" sort="Sen, Arindom" uniqKey="Sen A" first="Arindom" last="Sen">Arindom Sen</name></author><author><name sortKey="Behie, Leo A" sort="Behie, Leo A" uniqKey="Behie L" first="Leo A" last="Behie">Leo A. Behie</name></author><author><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18341411</idno><idno type="pmid">18341411</idno><idno type="doi">10.3171/FOC/2008/24/3-4/E7</idno><idno type="wicri:Area/PubMed/Corpus">001024</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001024</idno><idno type="wicri:Area/PubMed/Curation">001024</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001024</idno><idno type="wicri:Area/PubMed/Checkpoint">001024</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001024</idno><idno type="wicri:Area/Ncbi/Merge">000887</idno><idno type="wicri:Area/Ncbi/Curation">000887</idno><idno type="wicri:Area/Ncbi/Checkpoint">000887</idno><idno type="wicri:Area/Main/Merge">002323</idno><idno type="wicri:Area/Main/Curation">002139</idno><idno type="wicri:Area/Main/Exploration">002139</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats.</title><author><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Baghbaderani, Behnam A" sort="Baghbaderani, Behnam A" uniqKey="Baghbaderani B" first="Behnam A" last="Baghbaderani">Behnam A. Baghbaderani</name></author><author><name sortKey="Hong, Murray" sort="Hong, Murray" uniqKey="Hong M" first="Murray" last="Hong">Murray Hong</name></author><author><name sortKey="Lewington, Matthew" sort="Lewington, Matthew" uniqKey="Lewington M" first="Matthew" last="Lewington">Matthew Lewington</name></author><author><name sortKey="Phillips, Timothy" sort="Phillips, Timothy" uniqKey="Phillips T" first="Timothy" last="Phillips">Timothy Phillips</name></author><author><name sortKey="Mcleod, Marcus" sort="Mcleod, Marcus" uniqKey="Mcleod M" first="Marcus" last="Mcleod">Marcus Mcleod</name></author><author><name sortKey="Sen, Arindom" sort="Sen, Arindom" uniqKey="Sen A" first="Arindom" last="Sen">Arindom Sen</name></author><author><name sortKey="Behie, Leo A" sort="Behie, Leo A" uniqKey="Behie L" first="Leo A" last="Behie">Leo A. Behie</name></author><author><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name></author></analytic><series><title level="j">Neurosurgical focus</title><idno type="eISSN">1092-0684</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphetamine (pharmacology)</term><term>Animals</term><term>Behavior, Animal (drug effects)</term><term>Bioreactors</term><term>Cell Differentiation (physiology)</term><term>Cell Movement (physiology)</term><term>Cell Survival</term><term>Central Nervous System (cytology)</term><term>Central Nervous System (embryology)</term><term>Central Nervous System Stimulants</term><term>Disease Models, Animal</term><term>Embryonic Stem Cells (physiology)</term><term>Female</term><term>Fetus</term><term>Humans</term><term>Neurons (physiology)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Rats</term><term>Rats, Wistar</term><term>Stem Cell Transplantation (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amphetamine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Central Nervous System</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Central Nervous System</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Differentiation</term><term>Cell Movement</term><term>Embryonic Stem Cells</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bioreactors</term><term>Cell Survival</term><term>Central Nervous System Stimulants</term><term>Disease Models, Animal</term><term>Female</term><term>Fetus</term><term>Humans</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fetal tissue transplantation for Parkinson disease (PD) has demonstrated promising results in experimental and clinical studies. However, the widespread clinical application of this therapeutic approach is limited by a lack of fetal tissue. Human neural precursor cells (HNPCs) are attractive candidates for transplantation because of their long-term proliferation activity. Furthermore, these cells can be reproducibly expanded in a standardized fashion in suspension bioreactors. In this study the authors sought to determine whether the survival, differentiation, and migration of HNPCs after transplantation depended on the region of precursor cell origin, intracerebral site of transplantation, and duration of their expansion.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Baghbaderani, Behnam A" sort="Baghbaderani, Behnam A" uniqKey="Baghbaderani B" first="Behnam A" last="Baghbaderani">Behnam A. Baghbaderani</name><name sortKey="Behie, Leo A" sort="Behie, Leo A" uniqKey="Behie L" first="Leo A" last="Behie">Leo A. Behie</name><name sortKey="Hong, Murray" sort="Hong, Murray" uniqKey="Hong M" first="Murray" last="Hong">Murray Hong</name><name sortKey="Lewington, Matthew" sort="Lewington, Matthew" uniqKey="Lewington M" first="Matthew" last="Lewington">Matthew Lewington</name><name sortKey="Mcleod, Marcus" sort="Mcleod, Marcus" uniqKey="Mcleod M" first="Marcus" last="Mcleod">Marcus Mcleod</name><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name><name sortKey="Phillips, Timothy" sort="Phillips, Timothy" uniqKey="Phillips T" first="Timothy" last="Phillips">Timothy Phillips</name><name sortKey="Sen, Arindom" sort="Sen, Arindom" uniqKey="Sen A" first="Arindom" last="Sen">Arindom Sen</name></noCountry><country name="Canada"><noRegion><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002139 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002139 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:18341411
|texte= Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18341411" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |